Anti-herpes simplex virus activity of 5-substituted 2-pyrimidinone nucleosides

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Anti-herpes simplex virus activity of 5-substituted 2-pyrimidinone nucleosides.

Several 5-substituted 2-pyrimidinone 2'-deoxyribonucleoside (PdR) analogs were examined for their anti-herpes simplex virus (HSV) activity in cell culture. The order of potency of their antiviral activities against HSV type 1 (HSV-1) and HSV-2 was iodo PdR approximately ethynyl PdR approximately propynyl PdR. The antiviral action of iodo PdR is dependent on the ability of HSV to induce virus-sp...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1989

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.33.3.340